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Stopping Depo- Provera: Why and what to do about adverse experiences. April 1. 4, 2. 01.

We wish to thank all the women who’ve shared their experiences with Depo- Provera in the two years since this blog post was published. Comments are now closed. Those concerned about Depo- Provera and bone density may want to read Dr. Prior’s article on Depo- Provera Use and Bone Health recently posted on the website of the Centre for Menstrual Cycle and Ovulation Research. Laura Wershler and Dr.

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Coming off Depo- Provera is a women’s worst nightmare (April 4, 2. I thought it was time to revisit this topic. That blog post has become a forum for women to share their negative experiences with stopping Depo- Provera (also called “the shot,” or Depo), the four- times- a- year contraceptive injection. They report that health- care professionals seem unable to explain their problems or to offer effective solutions. What is puzzling for many is why they are experiencing symptoms like sore breasts, heavy and ongoing bleeding (or not getting flow back at all), digestive problems, weight gain and mood issues when they stop Depo.

This post aims to briefly explain how Depo works to prevent pregnancy, its common side effects and, most importantly, why and what to do about adverse experiences when stopping it. What follows is my interview with Dr.

Prior, Society for Menstrual Cycle Research board member, professor of endocrinology at the University of British Columbia, and scientific director of the Centre for Menstrual Cycle and Ovulation Research (Ce. MCOR) Section 1 explains how Depo- Provera works and what causes its side effects. Section 2  explains the symptoms women are experiencing after stopping the drug.

April 14, 2015 We wish to thank all the women who’ve shared their experiences with Depo-Provera in the two years since this blog post was published. Comments are. Read and follow your favourite manga on this new, fast, no hassle online manga reader. Come join us!

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Taking Depo- Provera: How it works and established side effects. Laura Wershler (LW): Dr. Prior, what is Depo- Provera. Depo is a shot of MPA given every three months in the large dose of 1. Depo prevents pregnancy by “drying up” the cervical mucus so sperm have trouble swimming, by thinning the endometrium (uterine lining) so a fertilized egg can’t implant and primarily by suppressing the hypothalamic and pituitary signals that coordinate the menstrual cycle. That means a woman’s own hormone levels become almost as low as in menopause, with very low progesterone and lowered estrogen levels.

LW: Could you explain the hormonal changes behind the several established side effects of Depo? Let’s start with bleeding issues including spotting, unpredictable or non- stop bleeding that can last for several months before, in most women, leading to amenorrhea (no menstrual period). Ask Jerilynn: It is not entirely clear, but probably the initial unpredictable bleeding relates to how long it takes for this big hormone injection to suppress women’s own estrogen levels. The other reason is that where the endometrium has gotten thin it is more likely to break down and bleed. These unpredictable flow side- effects of Depo are something that women should expect and plan for since they occur in the early days of use for every woman. After the first year of Depo (depending on the age and weight of the woman) about a third of women will have no more bleeding.

LW: What about headaches and depression? Ask Jerilynn: It is not clear why headaches increase on Depo—they tend not to be serious migraine headaches but are more stress type. Perhaps they are related to the higher stress hormones the body makes whenever estrogen levels drop.

Unfortunately, headaches tend to increase over time, rather than getting better as the not- so- funny bleeding does. The reasons for depression are mysterious to me but this is an important adverse effect. I believe that anyone who has previously had an episode of depression (whether diagnosed or not, but sufficient to interfere with life and work) should avoid Depo. LW: Although there has been little discussion about bone health concerns on the previous blog post, I think we should address the fact that Depo causes bone loss. How does it do this?

Ask Jerilynn: As we discussed, Depo causes estrogen levels to drop. Dropping estrogen levels always cause bone loss. Several randomized, blinded studies for example, have shown that if women taking Depo wear an estrogen patch, compared with a placebo patch, they don’t lose bone. MPA, like progesterone, stimulates new bone to form but this formation is not visible while bone loss is high (as in, while taking Depo). The increase in bone density on stopping Depo is because rising estrogen levels prevent bone loss and the increased bone formation then becomes visible. I have tended to think the bone loss is not an important problem because the bone density returns to normal.

However, women at osteoporosis risk do have more broken bones while on Depo. Therefore I recommend that all woman choosing Depo for contraception have at least three high calcium (dairy or calcium- fortified) foods per day (or take one 5. IU of vitamin D3 daily. It is probably wise for teens to avoid Depo if they have a personal history of amenorrhea (no flow for three or more months), or a close relative (mother, grandfather or sister) who had a broken bone without a major fall. What’s going on? Ask Jerilynn: The suppression of women’s estrogen production likely causes the weight gain on Depo (that averages 2 kg or five pounds in the first year).

A similar weight gain occurs in women or in animals when their ovaries are removed. It is probably the body’s way of trying to increase fat (that can convert male and stress hormones into estrogen) and thus to prevent the rapid bone loss that happens when estrogen levels drop. LW: Another reported effect of Depo is digestive problems.

I’ve read that abdominal distress including cramps, bloating and constipation are common because Depo loosens the tone of the muscles in the gastrointestinal tract. Can you comment on this? Ask Jerilynn:  I don’t really understand this. What I do know is that abdominal problems are common in general for women and haven’t shown up as significantly different between women on Depo or placebo in trials of Depo. I suspect, again, that the drop in estrogen level triggers stress hormones that cause crampy gut pain and changes in bowel habits. Stopping Depo- Provera: What is causing adverse effects and what to do about them. LW: Thanks for explaining the side effects women experience while taking Depo.

What happens and why are women miserable when they stop it? Ask Jerilynn: First let me say that I have looked in the recent medical literature and been unable to find any studies of women’s experiences on stopping Depo. One would surely hope that drug regulatory bodies have required research on the return to fertility in women taking Depo. Here’s what I think is happening, and I’ve formed this understanding based on what women described in their posts: Women’s reproduction has been suppressed by Depo for months or years. This means that (figuratively speaking) the hypothalamus, pituitary and ovaries have . The result is erratic but high estrogen levels causing nausea, sore breasts, fluid retention and abdominal bloating, mood swings and heavy or prolonged vaginal bleeding. With high estrogen levels and weight gain, plus the “hypothalamic incoordination,” ovulation doesn’t occur and therefore no progesterone is produced.

Progesterone – the hormone produced after ovulation in normal menstrual cycles – is needed to counterbalance the high estrogen levels. I believe that it is this estrogen- progesterone imbalance that is leading to all these miserable symptoms. LW: Many women who have shared their experiences on my previous post also seem very concerned by the delayed return to normal menstrual cycles, with some experiencing no bleeding for months. Others seem to have flooding and continual flow.

Full Attraction List . E., Windsor. Lil’ Heart and Soul Inn. Lil’ Heart and Soul Inn. The Heart and Soul Inn is a Boutique Inn situated on a quiet tree- lined street in a Victorian home built in 1. The home has been beautifully restored and fully upgraded with designer d.

Each suite is equipped with a ceiling fan, a flat screen TV with cable, a Blue Ray player, and Netflix. Each room has a private en suite bathroom.

Mill Street West, Kingsville. Stacks. Stacks. Serving up gourmet pancakes along with fabulous breakfast and lunch fare. Open seven days a week! Itunes Movies For Ipod The Wall (2017) there. Please note we do not take reservations.

Seating is first come, first serve. Open daily 8 am – 3 pm. Facebook: Windsor. Stacks. 19. 50 Lauzon Rd., Windsor. Breakout Kingsville. Breakout Kingsville. You are up against time – 4.

What are you looking to find – are you looking to escape or are you looking for someone? At Breakout Canada – Kingsville, we have a choice of five themed rooms to escape. We are also the world’s only character based escape rooms where you choose your role to help your team navigate each room. Are you the Oracle with the power to see the future?

Or the Timebender with the power to add precious seconds to your escape? The Lightbringer or maybe the Assassin? The Scholar or the Lockmaster? An all around surreal experience is to be had by all and we truly are excited to host you at Breakout Canada’s Kingsville location! Facebook: Breakout Canada – Kingsville – Surreal Escape Experience. Wigle Ave., Kingsville. Summer Wave Rentals.

Summer Wave Rentals. Pedal boat, tube and kayak rentals by the hour, 1/2 or full day. Group rates available. Pedal Boating. Let your mind unwind.

With our tubes, you can float for hours. Like a little excitement? Ride the waves on those windy days. Kayaking. Whether you are a first time novice or an experienced kayak- er, Colchester Beach can offer conditions to challenge you. Facebook: Summer Wave Rentals.

Colchester Beach – 1. Jackson St., Colchester. Riverfront Festival Plaza. Riverfront Festival Plaza. Festival Plaza is located in the heart of the city, along the banks of the Detroit River, directly across from Caesars Windsor. With over 1. 00,0. Festival Plaza, Windsor.

Amherstburg Chamber of Commerce. Amherstburg Chamber of Commerce. Enjoy shopping in Amherstburg where you will find everything you are looking from proud small business owners. There is no shopping mall or outlet centre here! From fashion to decor to art, there is something for everyone. This interactive map provided by the Amherstburg Chamber of Commerce will list businesses and locate them for you.

For more information about Amherstburg’s Chamber of Commerce visit their website at www. Dalhousie St, Amherstburg, ON N9.

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Coming soon! 5. 19. Concession 5 N, Amherstburg. Kona Sushi. Kona Sushi. Open Mon 4 pm – 9 pm, Tues – Thurs 1. Fri & Sat 1. 1: 3.

Sun 1. 2 pm – 3 pm & 5 pm – 9 pm. Wyandotte St E, Windsor. Paddle Anywhere. Paddle Anywhere. Paddle Anywhere offers kayak, canoe and SUP rentals. We also offer use of our patio for various occasions. Our purpose is to get family, friends and couples out onto our local waterways to enjoy all there is to see in our own backyard!

You can launch directly from our place onto Little River and head out to the Detroit River. We also allow you to pick up your vessel and travel to any of the other awesome you care to venture to! Facebook: Paddle Anywhere. Paddle Anywhere – 8. Riverdale Ave Windsor, ON1.

Coffee Co. 1. 4th Coffee Co. Coffee Co. Don’t go before picking up some fresh- roasted beans or one of their awesome gift- baskets that include all things for coffee- lovers. Open weekends 1. 1 am – 3 pm. Facebook: 1. 4th. Coffee. Co. 14. 45.

Concession Road 1. Essex. Ford City Walking Tour. Ford City Walking Tour.

The area known as Ford City developed out of a French parish, Notre Dame du Lac, founded in 1. Francois Drouillard. The church, now named Our Lady of the Rosary ( a. Holy Rosary), was built in 1.

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His son, Gordon Morton Mc. Gregor, became the Wagon Works president and, thanks to Henry Ford’s vision, became head of the fledgling Ford Motor Company of Canada in 1.

As Ford Motor Company grew, the surrounding area became a boom town. By 1. 91. 3, there were 1. That year, the village was incorporated.

In 1. 91. 5, it achieved town status. Unlike its orderly neighbour, Walkerville, Ford City grew haphazardly with little regard for planning. In 1. 92. 8- 2. 9, with 1. European countries to join the Ford work force, Ford City was incorporated as East Windsor. Ford Motor Company flourished throughout World War II, producing heavy trucks for the European theatre. But the end of the war brought labour unrest and, in the fall of 1.

Days’. The resulting agreement, called the Rand Formula after the arbitrator who designed it, was less than universally welcomed, but it set the tone for future development of trade unions and the role of management. The removal of the Ford head office and assembly plant to Oakville, near Toronto, occurred in 1. Ford City declined as the population dispersed, and little is left now of the town that Ford built. Drouillard Rd., Windsor. Walkerville Walking Tour. Walkerville Walking Tour.

The former Town of Walkerville was founded by Hiram Walker in 1. The New England- born distiller bought two French farms on the south shore of the Detroit River, and the growth of his industry and the town it supported continued for seven decades.

Railroads played an important part in Walkerville’s history. First, the Great Western’s extension to Windsor in 1.

Lake Erie Essex & Detroit River Railroad, which connected Walkerville with lakeshore towns and farms. The availability of rail transportation attracted other industrial enterprises to the area, and brought great prosperity to the Walker family and their town. All of the community’s amenities were provided by Walker – a fire brigade and police, streetlights, sewers, paved roads and sidewalks, parks, a music hall, a school, library and church. The Second Phase – An Edwardian Town on the Garden City Plan. While Hiram Walker’s original developments concentrated mainly on the business/commercial areas of town, his sons’ residential neighbourhood continued to grow until the City of Windsor annexed the town in 1. By 1. 90. 1 the Walkers sold their expanded Lake Erie & Detroit River Railway and used the funds to develop their land between Wyandotte and Richmond Streets. The interrupted street pattern reduced the traffic, keeping the park- like setting quiet, and the Walkers used this feature to promote a fine residential neighbourhood focused around St.

Mary’s Church and Willistead. Since lots were sold only to those who could build homes of at least 3. Every home Albert Kahn designed shows Arts and Crafts influence. Kahn believed that historic period styles were best suited to homes and public institutions, while factories should be utilitarian, brightly illuminated and devoid of ornament.

By the 1. 92. 0s many architects believed that the simplicity of factories should be models for all types of construction. Except for some changes since the amalgamation, most of this Walker- built town still survives. If conservation persists, this planned, century old, self- sufficient town will be a cultural treasure for Windsor and North America. Tour participants are reminded that many of the properties herein are private residences,and should be viewed with discretion. Starting Point: Hiram Walker & Sons Ltd.

E., Windsor. Victoria Avenue Walking Tour. Victoria Avenue Walking Tour. From the outset, Victoria Avenue was intended to be a gracious, residential street.

As a result, the earliest houses, built between 1. Stock Market “Crash” of 1.

They were the valued residences of some of the most influential and respected families during this middle period in Windsor’s evolution – doctors, merchants,lawyers, educators, politicians and industrialists whose ideas molded this municipality.